Hypersonic missiles have become the cutting-edge weapon in the game of great powers， causing a serious impact on the existing missile defense system. In response to the hypersonic missile threat， a distributed grid-based interception tactics is proposed， which helps to realize the innovative development from layered defense to distributed defense. The proposed method embodies the advantages of distributed and flexible operations， satisfies the rapid response requirements of anti-missile operations， and is feasible to realize the real-time optimization of interception planning in a large defense depth. The grid deployment model and the interception planning process based on short-term trajectory prediction are given. Under the scenario of anti-hypersonic cruise missile， the proposed method is preliminarily demonstrated， and the operational principles are summarized. With the detection support of space-based networking， this method can effectively deal with the major threat caused by the strong maneuvering of hypersonic missiles by using short-term prediction of the target trajectory.